S10 Text: Comparing RCPs of Dnmt3-Knockout Lines with Those of Wildtype Lines

The relative contributions of conservative processes are expected to be more substantial when the fraction of methylation events achieved through maintenance-type activity is elevated through loss of one or both of the de novo enzymes. Indeed, at the Lep locus, we inferred RCP values of 8.11 for Dmnt3a KO cells, a value significantly higher than that for wildtype cells (p = 0.046, two-tailed PT; S2 Fig a; S3 Table). Although the point estimate was higher for Dmnt3b KO cells as well, the difference was not significant (p = 0.11, two-tailed PT).